Напредък на изследванията по анализ на живак в Cinnabar и неговите препарати
Cinnabar is a commonly used mineral medicinal material in my country. It is obtained by mining and processing cinnabar ore of the sulfide mineral cinnabar family. According to traditional Chinese medicine theory, it is sweet, slightly cold, toxic, and belongs to the heart meridian. It has the effects of clearing the heart and calming the nerves, calming the Умът, подобряването на зрението и детоксикиращото . Използва се за лечение на сърцебиене, безсъние, епилепсия, инфантилни конвулсии, замъглено зрение, язви на уста Ефект . Въпреки това, тъй като съдържа 86% живак, безопасността на този лекарствен материал и неговите препарати е противоречива .
The main chemical component of cinnabar is natural mercuric sulfide (HgS), which is a stable covalently bonded compound with very low solubility. It is insoluble in water, organic solvents, hot hydrochloric acid and nitric acid. Modern research believes that mercuric sulfide is difficult to be absorbed by the human body. Other mercury compounds that can dissolve or solubilize in the gastrointestinal tract are the active ingredients of cinnabar that produce pharmacological and toxicological effects. On the other hand, the toxicity of mercury depends largely on its form of existence. Mercury forms include elemental mercury (mercury vapor and liquid mercury), inorganic mercury (such as mercuric chloride, mercuric acetate) and organic mercury (such as methylmercury, ethylmercury, phenylmercury). Among organic mercury, alkylmercury is more toxic than both arylmercury and inorganic mercury, and among alkylmercury, methylmercury is the most toxic [2]. Therefore, the study of the toxicity and pharmacological mechanism of cinnabar must take into account the state of mercury in the drug, its dissolution and absorption in the gastrointestinal tract, and its transformation, accumulation and excretion of morphological and valence states in the body. These processes cannot be simply expressed by the total amount of mercury, but need to rely on Методи за откриване на различни форми и валентни състояния .
С разработването на аналитични технологии изследванията върху химическата композиция на Cinnabar и неговите подготовки постигнаха голям напредък, но все още не е съобщено за обширна и систематична дискусия . Следователно е необходимо да се обобщи напредъка на аналитичните изследвания на Меркурий в Cinnabar и неговите препарати за предоставяне на препратка към контрола на качеството на свързаните с тях наркотици и рационални клинични употреби на наркотици {.}}}}}.
